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Research in these events is complicated because cannabis is often used in conjunction with tobacco, and drugs such as alcohol and cocaine.
These putative effects can be taken in context of a wide range of cardiovascular phenomena regulated by the endocannabinoid system and an overall role of cannabis in causing decreased peripheral resistance and increased cardiac output, which potentially could pose a threat to those with cardiovascular disease.
Most of the illicit drug emergency room visits involved multiple drugs.
Heavy, long term exposure to marijuana may have biologically-based physical, mental, behavioral and social health consequences and may be "associated with diseases of the liver (particularly with co-existing hepatitis C), lungs, heart, and vasculature".
At higher doses, effects can include altered body image, auditory and/or visual illusions, pseudohallucinations and ataxia from selective impairment of polysynaptic reflexes.
Cannabis was ranked 11th in dependence, 17th in physical harm, and 10th in social harm.Acute effects may include anxiety and panic, impaired attention, and memory (while intoxicated), an increased risk of psychotic symptoms, and possibly an increased risk of accidents if a person drives a motor vehicle while intoxicated.According to the United States Department of Health and Human Services, there were 455,000 emergency room visits associated with cannabis use in 2011.Cannabis is believed to be an aggravating factor in rare cases of arteritis, a serious condition that in some cases leads to amputation.Because 97% of case-reports also smoked tobacco, a formal association with cannabis could not be made.
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